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Supraphysiological Levels of IL-2 in Jak3-Deficient Mice Promote Strong Proliferative Responses of Adoptively Transferred Naive CD8(+) T Cells

The antigen-independent, strong proliferative responses of naive CD8(+) T cells have been well demonstrated in a particular strain of mice lacking IL-2 receptors. This type of proliferation is mainly driven by common gamma-chain (γ(c)) cytokines, such as IL-2, IL-7, and IL-15, present at abnormally...

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Detalles Bibliográficos
Autores principales: Lee, Gil-Woo, Lee, Sung-Woo, Kim, Juhee, Ju, Young-Jun, Kim, Hee-Ok, Yun, Cheol-Heui, Cho, Jae-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876067/
https://www.ncbi.nlm.nih.gov/pubmed/33584707
http://dx.doi.org/10.3389/fimmu.2020.616898