Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects

The most common oxidative DNA lesion is 8-oxoguanine which is mainly recognized and excised by the 8-oxoG DNA glycosylase 1 (OGG1), initiating the base excision repair (BER) pathway. Telomeres are particularly sensitive to oxidative stress (OS) which disrupts telomere homeostasis triggering genome i...

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Detalles Bibliográficos
Autores principales: Baquero, Juan Miguel, Benítez-Buelga, Carlos, Rajagopal, Varshni, Zhenjun, Zhao, Torres-Ruiz, Raúl, Müller, Sarah, Hanna, Bishoy M. F., Loseva, Olga, Wallner, Olov, Michel, Maurice, Rodríguez-Perales, Sandra, Gad, Helge, Visnes, Torkild, Helleday, Thomas, Benítez, Javier, Osorio, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876102/
https://www.ncbi.nlm.nih.gov/pubmed/33568707
http://dx.doi.org/10.1038/s41598-021-82917-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876102/
https://www.ncbi.nlm.nih.gov/pubmed/33568707
http://dx.doi.org/10.1038/s41598-021-82917-7

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