Cargando…

Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects

The most common oxidative DNA lesion is 8-oxoguanine which is mainly recognized and excised by the 8-oxoG DNA glycosylase 1 (OGG1), initiating the base excision repair (BER) pathway. Telomeres are particularly sensitive to oxidative stress (OS) which disrupts telomere homeostasis triggering genome i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baquero, Juan Miguel, Benítez-Buelga, Carlos, Rajagopal, Varshni, Zhenjun, Zhao, Torres-Ruiz, Raúl, Müller, Sarah, Hanna, Bishoy M. F., Loseva, Olga, Wallner, Olov, Michel, Maurice, Rodríguez-Perales, Sandra, Gad, Helge, Visnes, Torkild, Helleday, Thomas, Benítez, Javier, Osorio, Ana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876102/ https://www.ncbi.nlm.nih.gov/pubmed/33568707 http://dx.doi.org/10.1038/s41598-021-82917-7

Ejemplares similares

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
por: Visnes, Torkild, et al.
Publicado: (2020)

OGG1 Inhibition Triggers Synthetic Lethality and Enhances The Effect of PARP Inhibitor Olaparib in BRCA1-Deficient TNBC Cells
por: Baquero, Juan Miguel, et al.
Publicado: (2022)

Synthetic switches of OGG1 control initiation of base excision repair and offer new treatment strategies
por: Benitéz‐Buelga, Carlos, et al.
Publicado: (2022)

OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions
por: Hanna, Bishoy M. F., et al.
Publicado: (2020)

NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis
por: Zhao, Zhenjun, et al.
Publicado: (2021)

NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487
por: Hanna, Bishoy M. F., et al.
Publicado: (2021)

Molecular insights into the OGG1 gene, a cancer risk modifier in BRCA1 and BRCA2 mutations carriers
por: Benitez-Buelga, Carlos, et al.
Publicado: (2016)

Optimization of N‐Piperidinyl‐Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8‐Oxo‐Guanine DNA Glycosylase 1
por: Wallner, Olov, et al.
Publicado: (2022)

Pharmacological OGG1 inhibition decreases murine allergic airway inflammation
por: Tanner, Lloyd, et al.
Publicado: (2022)

AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma
por: Das, Ishani, et al.
Publicado: (2020)

A common SNP in the UNG gene decreases ovarian cancer risk in BRCA2 mutation carriers
por: Baquero, Juan Miguel, et al.
Publicado: (2019)

Karonudib is a promising anticancer therapy in hepatocellular carcinoma
por: Hua, Xiangwei, et al.
Publicado: (2019)

Computational and Experimental Druggability Assessment of Human DNA Glycosylases
por: Michel, Maurice, et al.
Publicado: (2019)

Genetic variation in the NEIL2 DNA glycosylase gene is associated with oxidative DNA damage in BRCA2 mutation carriers
por: Benítez-Buelga, Carlos, et al.
Publicado: (2017)

OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced cellular senescence
por: De Rosa, Mariarosaria, et al.
Publicado: (2023)

Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses
por: Tampere, Marianna, et al.
Publicado: (2020)

The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions
por: Orta, Manuel Luis, et al.
Publicado: (2014)

Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model
por: Tanner, L., et al.
Publicado: (2023)

Systematic review: predictive value of organoids in colorectal cancer
por: Sakshaug, B. Cristoffer, et al.
Publicado: (2023)

Genetic Anticipation Is Associated with Telomere Shortening in Hereditary Breast Cancer
por: Martinez-Delgado, Beatriz, et al.
Publicado: (2011)

Hydroxyethylcellulose as a methotrexate carrier in anticancer therapy
por: Ciekot, Jarosław, et al.
Publicado: (2020)

The role of cysteines in the structure and function of OGG1
por: Wang, Katarina, et al.
Publicado: (2020)

hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia
por: Eshtad, S, et al.
Publicado: (2016)

MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
por: Sanjiv, Kumar, et al.
Publicado: (2021)

Anticancer Conjugates and Cocktails Based on Methotrexate and Nucleoside Synergism
por: Vortherms, Anthony R., et al.
Publicado: (2009)

Hydroxyethyl starch as an effective methotrexate carrier in anticancer therapy
por: Goszczyński, T M, et al.
Publicado: (2014)

OGG1 in the Kidney: Beyond Base Excision Repair
por: Zhao, Fan, et al.
Publicado: (2022)

Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys(326) polymorphic variant
por: Luna, Luisa, et al.
Publicado: (2005)

Crossroads of telomere biology and anticancer drug discovery
por: Seimiya, Hiroyuki
Publicado: (2020)

Direct hOGG1-Myc interactions inhibit hOGG1 catalytic activity and recruit Myc to its promoters under oxidative stress
por: Bangalore, Disha M, et al.
Publicado: (2022)

Identification and characterization of OGG1 mutations in patients with Alzheimer's disease
por: Mao, Guogen, et al.
Publicado: (2007)

Microscopic mechanism of DNA damage searching by hOGG1
por: Rowland, Meng M., et al.
Publicado: (2014)

Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis
por: Kakehashi, Anna, et al.
Publicado: (2017)

Thermostability and excision activity of polymorphic forms of hOGG1
por: Mouzakis, Kathryn D., et al.
Publicado: (2019)

OGG1 in Lung—More than Base Excision Repair
por: Ma, Xiaodi, et al.
Publicado: (2022)

N-Methylpurine DNA Glycosylase and OGG1 DNA Repair Activities: Opposite Associations With Lung Cancer Risk
por: Leitner-Dagan, Yael, et al.
Publicado: (2012)

Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumors
por: Habib, Samy L, et al.
Publicado: (2008)

Mechanism of Activation of AMPK and Upregulation of OGG1 by Rapamycin in Cancer Cells
por: Habib, Samy L.
Publicado: (2011)

Expression of 8-oxoguanine DNA glycosylase (Ogg1) in mouse retina
por: Bigot, Karine, et al.
Publicado: (2009)

The roles of base excision repair enzyme OGG1 in gene expression
por: Wang, Ruoxi, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_4valntv48io451k68ora0m9g5e