TGF-β1-mediated transition of resident fibroblasts to cancer-associated fibroblasts promotes cancer metastasis in gastrointestinal stromal tumor

Cancer-associated fibroblasts (CAFs) are the most abundant cells in the tumor microenvironment. Crosstalk between tumor cells and CAFs contributes to tumor survival in most epithelial cancers. Recently, utilizing gastrointestinal stromal tumor (GIST) as a model for sarcomas, we identified paracrine...

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Detalles Bibliográficos
Autores principales: Yoon, Hyunho, Tang, Chih-Min, Banerjee, Sudeep, Delgado, Antonio L., Yebra, Mayra, Davis, Jacob, Sicklick, Jason K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876107/
https://www.ncbi.nlm.nih.gov/pubmed/33568624
http://dx.doi.org/10.1038/s41389-021-00302-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876107/
https://www.ncbi.nlm.nih.gov/pubmed/33568624
http://dx.doi.org/10.1038/s41389-021-00302-5

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