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TGF-β1-mediated transition of resident fibroblasts to cancer-associated fibroblasts promotes cancer metastasis in gastrointestinal stromal tumor
Cancer-associated fibroblasts (CAFs) are the most abundant cells in the tumor microenvironment. Crosstalk between tumor cells and CAFs contributes to tumor survival in most epithelial cancers. Recently, utilizing gastrointestinal stromal tumor (GIST) as a model for sarcomas, we identified paracrine...
Autores principales: | Yoon, Hyunho, Tang, Chih-Min, Banerjee, Sudeep, Delgado, Antonio L., Yebra, Mayra, Davis, Jacob, Sicklick, Jason K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876107/ https://www.ncbi.nlm.nih.gov/pubmed/33568624 http://dx.doi.org/10.1038/s41389-021-00302-5 |
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