Cargando…

Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission

Glia-mediated inflammatory processes are crucial in the pathogenesis of Parkinson’s disease (PD). As the most abundant cells of the brain and active participants in neuroinflammatory responses, astrocytes largely propagate inflammatory signals and amplify neuronal loss. Hence, intensive control of a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Nanshan, Zhu, Hong, Xu, Rong, Liu, Jiaqi, Fang, Yinquan, Zhang, Jing, Ding, Jianhua, Hu, Gang, Lu, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876245/ https://www.ncbi.nlm.nih.gov/pubmed/33584303 http://dx.doi.org/10.3389/fphar.2020.618992

Ejemplares similares

Corrigendum: Induced expression of kir6.2 in A1 astrocytes propagates inflammatory neurodegeneration via Drp1-dependent mitochondrial fission
por: Song, Nanshan, et al.
Publicado: (2023)

Kir6.2 is essential to maintain neurite features by modulating PM20D1-reduced mitochondrial ATP generation
por: Song, Nanshan, et al.
Publicado: (2021)

Metformin Protects Against Diabetes-Induced Cognitive Dysfunction by Inhibiting Mitochondrial Fission Protein DRP1
por: Hu, Yan, et al.
Publicado: (2022)

Silibinin Induces G2/M Cell Cycle Arrest by Activating Drp1-Dependent Mitochondrial Fission in Cervical Cancer
por: You, Yanting, et al.
Publicado: (2020)

Loss of the Mitochondrial Fission GTPase Drp1 Contributes to Neurodegeneration in a Drosophila Model of Hereditary Spastic Paraplegia
por: Fowler, Philippa C., et al.
Publicado: (2020)

Atractylenolide I Inhibits NLRP3 Inflammasome Activation in Colitis-Associated Colorectal Cancer via Suppressing Drp1-Mediated Mitochondrial Fission
por: Qin, Yao, et al.
Publicado: (2021)

β-arrestin1 regulates astrocytic reactivity via Drp1-dependent mitochondrial fission: implications in postoperative delirium
por: Hua, Fuzhou, et al.
Publicado: (2023)

Astragaloside IV Derivative (LS-102) Alleviated Myocardial Ischemia Reperfusion Injury by Inhibiting Drp1(Ser616) Phosphorylation-Mediated Mitochondrial Fission
por: Chen, Li, et al.
Publicado: (2020)

PDI-mediated S-nitrosylation of DRP1 facilitates DRP1-S616 phosphorylation and mitochondrial fission in CA1 neurons
por: Lee, Duk-shin, et al.
Publicado: (2018)

Antiepileptic Drugs Elevate Astrocytic Kir4.1 Expression in the Rat Limbic Region
por: Mukai, Takahiro, et al.
Publicado: (2018)

The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1
por: Liu, Raymond, et al.
Publicado: (2015)

A role for septin 2 in Drp1‐mediated mitochondrial fission
por: Pagliuso, Alessandro, et al.
Publicado: (2016)

Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport
por: Ramonett, Aaron, et al.
Publicado: (2022)

Is Drp1 sufficient to catalyze membrane fission?
por: Roy, Krishnendu, et al.
Publicado: (2022)

Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission
por: Rehklau, Katharina, et al.
Publicado: (2017)

ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1
por: Sonn, Seong Keun, et al.
Publicado: (2021)

Adrenergic Regulation of Drp1-Driven Mitochondrial Fission in Cardiac Physio-Pathology
por: Jhun, Bong Sook, et al.
Publicado: (2018)

DRP3 and ELM1 are required for mitochondrial fission in the liverwort Marchantia polymorpha
por: Nagaoka, Nagisa, et al.
Publicado: (2017)

Divide et Impera: Drp1-mediated Mitochondrial Fission in Glioma Malignancy
por: Eugenio-Pérez, Dianelena, et al.
Publicado: (2019)

Drp1-mediated mitochondrial fission promotes renal fibroblast activation and fibrogenesis
por: Wang, Yating, et al.
Publicado: (2020)

DRP1-Mediated Mitochondrial Fission Regulates Lung Epithelial Response to Allergen
por: Bruno, Sierra R., et al.
Publicado: (2021)

Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria
por: Yang, Huan, et al.
Publicado: (2022)

Suppressing DRP1-mediated mitochondrial fission and mitophagy increases mitochondrial apoptosis of hepatocellular carcinoma cells in the setting of hypoxia
por: Lin, Xia-Hui, et al.
Publicado: (2020)

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells
por: Otera, Hidenori, et al.
Publicado: (2010)

Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis
por: Li, Guobing, et al.
Publicado: (2014)

TRAP1 Controls Mitochondrial Fusion/Fission Balance through Drp1 and Mff Expression
por: Takamura, Hironori, et al.
Publicado: (2012)

Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after x-irradiation
por: Yamamori, Tohru, et al.
Publicado: (2015)

A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission
por: Macdonald, Patrick J., et al.
Publicado: (2014)

Lipopolysaccharide promotes Drp1‐dependent mitochondrial fission and associated inflammatory responses in macrophages
por: Kapetanovic, Ronan, et al.
Publicado: (2020)

The Mitochondrial Fission Regulator DRP1 Controls Post-Transcriptional Regulation of TNF-α
por: Gao, Fushan, et al.
Publicado: (2021)

All-Trans Retinoic Acid Increases DRP1 Levels and Promotes Mitochondrial Fission
por: Chidipi, Bojjibabu, et al.
Publicado: (2021)

Discovery, Characterization, and Structure–Activity Relationships of an Inhibitor of Inward Rectifier Potassium (Kir) Channels with Preference for Kir2.3, Kir3.X, and Kir7.1
por: Raphemot, Rene, et al.
Publicado: (2011)

The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR
por: Steffen, Janos, et al.
Publicado: (2022)

AMPK Activation Alleviates Myocardial Ischemia-Reperfusion Injury by Regulating Drp1-Mediated Mitochondrial Dynamics
por: Du, Jingxia, et al.
Publicado: (2022)

CL-705G: a novel chemical Kir6.2-specific K(ATP) channel opener
por: Gando, Ivan, et al.
Publicado: (2023)

Human Fis1 directly interacts with Drp1 in an evolutionarily conserved manner to promote mitochondrial fission
por: Nolden, Kelsey A., et al.
Publicado: (2023)

Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission
por: Zhao, Jian, et al.
Publicado: (2011)

ROCK1 activation-mediated mitochondrial translocation of Drp1 and cofilin are required for arnidiol-induced mitochondrial fission and apoptosis
por: Hu, Jinjiao, et al.
Publicado: (2020)

DRP1-dependent mitochondrial fission initiates follicle cell differentiation during Drosophila oogenesis
por: Mitra, Kasturi, et al.
Publicado: (2012)

MUTANT HUNTINGTIN BINDS THE MITOCHONDRIAL FISSION GTPASE DRP1 AND INCREASES ITS ENZYMATIC ACTIVTY
por: Song, Wenjun, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_n4jbkj9n3loldnm0t1mn1ijes6