Low-Density Granulocytes Affect T-SPOT.TB Assay by Inhibiting the Production of Interferon-γ in T Cells via PD-L1/PD-1 Pathway

BACKGROUND: T-SPOT TB (T-SPOT) assay is widely used for detection of Mycobacterium tuberculosis infection that is based on the detection of M. tuberculosis-specific interferon-γ-secreting T cells (ISCs) in peripheral blood mononuclear cells (PBMCs). Recently, high frequencies of low-density granuloc...

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Detalles Bibliográficos
Autores principales: Rao, Jiayue, Su, Rigu, Peng, Yiping, Guo, Yang, Huang, Zikun, Ye, Yutao, Gao, Yujie, Liu, Jun, Zhang, Lu, Luo, Qing, Li, Junming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876290/
https://www.ncbi.nlm.nih.gov/pubmed/33584591
http://dx.doi.org/10.3389/fmicb.2020.622389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876290/
https://www.ncbi.nlm.nih.gov/pubmed/33584591
http://dx.doi.org/10.3389/fmicb.2020.622389

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