Human‐specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression

Compared with our closest living evolutionary cousins, humans appear unusually prone to develop carcinomas (cancers arising from epithelia). The SIGLEC12 gene, which encodes the Siglec‐XII protein expressed on epithelial cells, has several uniquely human features: a fixed homozygous missense mutatio...

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Detalles Bibliográficos
Autores principales: Siddiqui, Shoib S, Vaill, Michael, Do, Raymond, Khan, Naazneen, Verhagen, Andrea L, Zhang, Wu, Lenz, Heinz‐Josef, Johnson‐Pais, Teresa L, Leach, Robin J, Fraser, Gary, Wang, Charles, Feng, Gen‐Sheng, Varki, Nissi, Varki, Ajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876704/
https://www.ncbi.nlm.nih.gov/pubmed/33615152
http://dx.doi.org/10.1096/fba.2020-00092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876704/
https://www.ncbi.nlm.nih.gov/pubmed/33615152
http://dx.doi.org/10.1096/fba.2020-00092

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