Suberoylanilide hydroxamic acid enhances the radiosensitivity of lung cancer cells through acetylated wild-type and mutant p53-dependent modulation of mitochondrial apoptosis

OBJECTIVE: Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, has shown potential as a candidate radiosensitizer for many types of cancers. This study aimed to explore the radiosensitization mechanism of SAHA in lung cancer cells. METHODS: Mutations in p53 were generated by sit...

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Detalles Bibliográficos
Autores principales: Wu, Kan, Chen, Xueqin, Chen, Xufeng, Zhang, Shirong, Xu, Yasi, Xia, Bing, Ma, Shenglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Pre-Clinical Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876760/
https://www.ncbi.nlm.nih.gov/pubmed/33557658
http://dx.doi.org/10.1177/0300060520981545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876760/
https://www.ncbi.nlm.nih.gov/pubmed/33557658
http://dx.doi.org/10.1177/0300060520981545

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