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The CRK2-CYC13 complex functions as an S-phase cyclin-dependent kinase to promote DNA replication in Trypanosoma brucei

BACKGROUND: Faithful DNA replication is essential to maintain genomic stability in all living organisms, and the regulatory pathway for DNA replication initiation is conserved from yeast to humans. The evolutionarily ancient human parasite Trypanosoma brucei, however, lacks many of the conserved DNA...

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Detalles Bibliográficos
Autores principales: Lee, Kyu Joon, Li, Ziyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876812/
https://www.ncbi.nlm.nih.gov/pubmed/33568178
http://dx.doi.org/10.1186/s12915-021-00961-1