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Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH
Macrophage-mediated inflammation is critical in the pathogenesis of non-alcoholic steatohepatitis (NASH). Here, we describe that, with high-fat, high-sucrose-diet feeding, mature TIM4(pos) Kupffer cells (KCs) decrease in number, while monocyte-derived Tim4(neg) macrophages accumulate. In concert, mo...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877246/ https://www.ncbi.nlm.nih.gov/pubmed/33440159 http://dx.doi.org/10.1016/j.celrep.2020.108626 |