A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity

The microtubule-associated protein Tau is strongly implicated in Alzheimer’s disease (AD) and aggregates into neurofibrillary tangles in AD. Genetic reduction of Tau is protective in several animal models of AD and cell culture models of amyloid-β (Aβ) toxicity, making it an exciting therapeutic tar...

Descripción completa

Detalles Bibliográficos
Autores principales: Rush, Travis, Roth, Jonathan R., Thompson, Samantha J., Aldaher, Adam R., Cochran, J. Nicholas, Roberson, Erik D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877553/
https://www.ncbi.nlm.nih.gov/pubmed/31698056
http://dx.doi.org/10.1016/j.nbd.2019.104668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877553/
https://www.ncbi.nlm.nih.gov/pubmed/31698056
http://dx.doi.org/10.1016/j.nbd.2019.104668

Ejemplares similares