Coproporphyrin I Can Serve as an Endogenous Biomarker for OATP1B1 Inhibition: Assessment Using a Glecaprevir/Pibrentasvir Clinical Study

Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 are involved in the disposition of a variety of commonly prescribed drugs. The evaluation of OATP1B1/1B3 inhibition potential by investigational drugs is of interest during clinical drug development due to various adverse events associate...

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Detalles Bibliográficos
Autores principales: Kalluri, Hari V., Kikuchi, Ryota, Coppola, Sheryl, Schmidt, Jeffrey, Mohamed, Mohamed‐Eslam F., Bow, Daniel A.J., Salem, Ahmed H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877830/
https://www.ncbi.nlm.nih.gov/pubmed/33048456
http://dx.doi.org/10.1111/cts.12888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877830/
https://www.ncbi.nlm.nih.gov/pubmed/33048456
http://dx.doi.org/10.1111/cts.12888

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