Cargando…

An Investigation of the Metabolism and Excretion of KD101 and Its Interindividual Differences: A Microtracing Mass Balance Study in Humans

The absorption, metabolism, and excretion (AME) profiles of KD101, currently under clinical development to treat obesity, were assessed in humans using accelerator mass spectrometry (AMS) after a single oral administration of KD101 at 400 mg and a microdose of (14)C‐KD101 at ~ 35.2 μg with a total r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Anhye, Dueker, Stephen R., Hwang, Jun Gi, Yoon, Jangsoo, Lee, Sang‐Won, Lee, Hye Suk, Yu, Byung‐Yong, Yu, Kyung‐Sang, Lee, Howard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877834/ https://www.ncbi.nlm.nih.gov/pubmed/33460293 http://dx.doi.org/10.1111/cts.12848

Ejemplares similares

Opportunities in low-level radiocarbon microtracing: applications and new technology
por: Vuong, Le Thuy, et al.
Publicado: (2015)

New tablet formulation of tacrolimus with smaller interindividual variability may become a better treatment option than the conventional capsule formulation in organ transplant patients
por: Kim, Yu Kyong, et al.
Publicado: (2017)

Clinical Pharmacokinetics of Daprodustat: Results of an Absorption, Distribution, and Excretion Study With Intravenous Microtracer and Concomitant Oral Doses for Bioavailability Determination
por: Mahar, Kelly M., et al.
Publicado: (2021)

Pharmacokinetics, Excretion, and Mass Balance of [(14)C]‐Batefenterol Following a Single Microtracer Intravenous Dose (Concomitant to an Inhaled Dose) or Oral Dose of Batefenterol in Healthy Men
por: Ambery, Claire, et al.
Publicado: (2018)

Pharmacokinetics, absorption, and excretion of radiolabeled revexepride: a Phase I clinical trial using a microtracer and accelerator mass spectrometry-based approach
por: Flach, Stephen, et al.
Publicado: (2016)

Pharmacokinetics, Biotransformation, and Excretion of [(14)C]Etelcalcetide (AMG 416) Following a Single Microtracer Intravenous Dose in Patients with Chronic Kidney Disease on Hemodialysis
por: Subramanian, Raju, et al.
Publicado: (2016)

The Absolute Bioavailability, Absorption, Distribution, Metabolism, and Excretion of BI 425809 Administered as an Oral Dose or an Oral Dose with an Intravenous Microtracer Dose of [(14)C]-BI 425809 in Healthy Males
por: Burkard, Ute, et al.
Publicado: (2021)

Correction to: The Absolute Bioavailability, Absorption, Distribution, Metabolism, and Excretion of BI 425809 Administered as an Oral Dose or an Oral Dose with an Intravenous Microtracer Dose of [(14)C]‑BI 425809 in Healthy Males
por: Burkard, Ute, et al.
Publicado: (2022)

A Phase 1 Study to Assess Mass Balance and Absolute Bioavailability of Zimlovisertib in Healthy Male Participants Using a (14)C‐Microtracer Approach
por: Singh, Ravi Shankar P., et al.
Publicado: (2022)

The Oral Bioavailability and Metabolism of Midazolam in Stable Critically Ill Children: A Pharmacokinetic Microtracing Study
por: van Groen, Bianca D., et al.
Publicado: (2020)

Proof of Concept: First Pediatric [(14)C]microtracer Study to Create Metabolite Profiles of Midazolam
por: van Groen, Bianca D., et al.
Publicado: (2020)

Novel Application of the Two‐Period Microtracer Approach to Determine Absolute Oral Bioavailability and Fraction Absorbed of Ertugliflozin
por: Raje, Sangeeta, et al.
Publicado: (2018)

A robust multivariate structure of interindividual covariation between psychosocial characteristics and arousal responses to visual narratives
por: Kim, Jinyoung, et al.
Publicado: (2022)

Population Pharmacokinetic−Pharmacodynamic Modeling of Carvedilol to Evaluate the Effect of Cytochrome P450 2D6 Genotype on the Heart Rate Reduction
por: Hwang, Sejung, et al.
Publicado: (2023)

Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a (14)C-microtracer and therapeutic dose in cancer patients
por: van Andel, L., et al.
Publicado: (2017)

Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a (26)Al Microtracer Approach
por: de Ligt, Rianne, et al.
Publicado: (2018)

Investigation of the human metabolism and disposition of the prolyl hydrolase inhibitor daprodustat using IV microtracer with Entero‐Test bile string
por: Tai, Guoying, et al.
Publicado: (2023)

Analysis of ENPP2 in the Uterine Endometrium of Pigs Carrying Somatic Cell Nuclear Transfer Cloned Embryos
por: Seo, Heewon, et al.
Publicado: (2013)

Correction to: Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a (14)C-microtracer and therapeutic dose in cancer patients
por: van Andel, L., et al.
Publicado: (2017)

A Phase 1, Open-Label Study in Healthy Subjects to Evaluate the Absolute Bioavailability of AG-221 by a Microtracer Approach
por: Wang, Xiaomin, et al.
Publicado: (2019)

Evaluation of Safety, Tolerability and Pharmacokinetic Characteristics of SA001 and Its Active Metabolite Rebamipide after Single and Multiple Oral Administration
por: Bae, Sungyeun, et al.
Publicado: (2023)

KdV & KAM
por: Kappeler, Thomas, et al.
Publicado: (2003)

Species, interindividual, and tissue specificity in endocrine signaling.
por: Walker, C, et al.
Publicado: (1999)

Interindividual variability in sweat electrolyte concentration in marathoners
por: Lara, Beatriz, et al.
Publicado: (2016)

Neuromodulation Reduces Interindividual Variability of Neuronal Output
por: Schneider, Anna C., et al.
Publicado: (2022)

Taking the chance!–Interindividual differences in rule-breaking
por: Cubillos-Pinilla, Leidy, et al.
Publicado: (2022)

Interindividual differences in Pavlovian influence on learning are consistent
por: Saeedpour, Sepehr, et al.
Publicado: (2023)

Comparison of the Pharmacokinetics of Highly Variable Drugs in Healthy Subjects Using a Partial Replicated Crossover Study: A Fixed-Dose Combination of Fimasartan 120 mg and Atorvastatin 40 mg versus Separate Tablets
por: Hwang, Jun Gi, et al.
Publicado: (2020)

Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form
por: Seo, Hyo Jung, et al.
Publicado: (2015)

Studying individual development in an interindividual context : a person-oriented approach /
por: Bergman, Lars R.
Publicado: (2003)

Krill Oil Inhibits Cholesterol Synthesis and Stimulated Cholesterol Excretion in Hypercholesterolemic Rats
por: Kim, Ok-Kyung, et al.
Publicado: (2022)

Influence of cytochrome P450 2D6 polymorphism on hippocampal white matter and treatment response in schizophrenia
por: Shin, Wonsuk, et al.
Publicado: (2021)

Effects of dietary protein levels on performance, nitrogen excretion, and odor emission of growing pullets and laying hens
por: Heo, Yun-Ji, et al.
Publicado: (2023)

Characterization of the absorption, metabolism, excretion, and mass balance of gefapixant in humans
por: Nussbaum, Jesse C., et al.
Publicado: (2022)

Interindividual variation in carcinogen metabolism and bladder cancer risk.
por: Vineis, P, et al.
Publicado: (1992)

Accountability Accentuates Interindividual-Intergroup Discontinuity by Enforcing Parochialism
por: Wildschut, Tim, et al.
Publicado: (2015)

Interindividual variation and consistency of migratory behavior in the Eurasian woodcock
por: Tedeschi, Alessandro, et al.
Publicado: (2020)

Combining Intra- and Interindividual Approaches in Epistemic Beliefs Research
por: Rosman, Tom, et al.
Publicado: (2020)

Heritability and interindividual variability of regional structure-function coupling
por: Gu, Zijin, et al.
Publicado: (2021)

Monocyte Differentiation and Heterogeneity: Inter-Subset and Interindividual Differences
por: Williams, Helen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_cna25847ahq7jtkfkrn6eg9r8e