Effect of SLCO1B1 Polymorphisms on High‐Dose Methotrexate Clearance in Children and Young Adults With Leukemia and Lymphoblastic Lymphoma

High‐dose (HD) methotrexate (MTX) is a critical component of treatment for hematologic malignancies in children and young adults. Therapeutic drug monitoring is necessary due to substantial interindividual variation in MTX clearance. Common function‐altering polymorphisms in SLCO1B1 (encodes OATP1B1...

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Detalles Bibliográficos
Autores principales: Schulte, Rachael R., Choi, Leena, Utreja, Nipun, Van Driest, Sara L., Stein, C. Michael, Ho, Richard H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877862/
https://www.ncbi.nlm.nih.gov/pubmed/32961024
http://dx.doi.org/10.1111/cts.12879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877862/
https://www.ncbi.nlm.nih.gov/pubmed/32961024
http://dx.doi.org/10.1111/cts.12879

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