Molecular modeling-guided optimization of acetylcholinesterase reactivators: A proof for reactivation of covalently inhibited targets

Covalent drugs have been intensively studied in some very important fields such as anti-tumor and anti-virus, including the currently global-spread SARS-CoV-2. However, these drugs may interact with a variety of biological macromolecules and cause serious toxicology, so how to reactivate the inhibit...

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Detalles Bibliográficos
Autores principales: Wei, Zhao, Yang, Jie, Liu, Yanqin, Nie, Huifang, Yao, Lin, Yang, Jun, Guo, Lei, Zheng, Zhibing, Ouyang, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877871/
https://www.ncbi.nlm.nih.gov/pubmed/33611189
http://dx.doi.org/10.1016/j.ejmech.2021.113286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877871/
https://www.ncbi.nlm.nih.gov/pubmed/33611189
http://dx.doi.org/10.1016/j.ejmech.2021.113286

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