Mass balance and pharmacokinetics of an oral dose of (14)C‐napabucasin in healthy adult male subjects

This phase 1, open‐label study assessed(14)C‐napabucasin absorption, metabolism, and excretion, napabucasin pharmacokinetics, and napabucasin metabolites (primary objectives); safety/tolerability were also evaluated. Eight healthy males (18–45 years) received a single oral 240‐mg napabucasin dose co...

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Detalles Bibliográficos
Autores principales: Dai, Xiaoshu, Karol, Michael D., Hitron, Matthew, Hard, Marjie L., Blanchard, John Evan, Eraut, Nicola C. J. E., Rich, Natalie, Gufford, Brandon T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878185/
https://www.ncbi.nlm.nih.gov/pubmed/33576192
http://dx.doi.org/10.1002/prp2.722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878185/
https://www.ncbi.nlm.nih.gov/pubmed/33576192
http://dx.doi.org/10.1002/prp2.722

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