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Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platforms
Huntington’s disease is caused by a CAG / polyglutamine repeat expansion. Mutated CAG repeats undergo somatic instability, resulting in tracts of several hundred CAGs in the brain; and genetic modifiers of Huntington’s disease have indicated that somatic instability is a major driver of age of onset...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878250/ https://www.ncbi.nlm.nih.gov/pubmed/33604571 http://dx.doi.org/10.1093/braincomms/fcaa231 |