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Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platforms

Huntington’s disease is caused by a CAG / polyglutamine repeat expansion. Mutated CAG repeats undergo somatic instability, resulting in tracts of several hundred CAGs in the brain; and genetic modifiers of Huntington’s disease have indicated that somatic instability is a major driver of age of onset...

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Detalles Bibliográficos
Autores principales:	Landles, Christian, Milton, Rebecca E, Jean, Alexandre, McLarnon, Stuart, McAteer, Sean J, Taxy, Bridget A, Osborne, Georgina F, Zhang, Chuangchuang, Duan, Wenzhen, Howland, David, Bates, Gillian P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878250/ https://www.ncbi.nlm.nih.gov/pubmed/33604571 http://dx.doi.org/10.1093/braincomms/fcaa231

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