Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy

T cell rejuvenation by PD-1/PD-L1 blockade, despite emerging as a highly promising therapy for advanced cancers, is only beneficial for a minority of treated patients. There is evidence that a lack of efficient T cell activation may be responsible for the failure. Here, we demonstrate that IL-21 can...

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Detalles Bibliográficos
Autores principales: Li, Ying, Cong, Yanni, Jia, Mingming, He, Qianqian, Zhong, Haiqing, Zhao, Yun, Li, Hang, Yan, Meining, You, Jia, Liu, Jia, Chen, Lieping, Hang, Haiying, Wang, Shengdian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878483/
https://www.ncbi.nlm.nih.gov/pubmed/33574265
http://dx.doi.org/10.1038/s41467-021-21241-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878483/
https://www.ncbi.nlm.nih.gov/pubmed/33574265
http://dx.doi.org/10.1038/s41467-021-21241-0

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