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Self-assembly and regulation of protein cages from pre-organised coiled-coil modules

Coiled-coil protein origami (CCPO) is a modular strategy for the de novo design of polypeptide nanostructures. CCPO folds are defined by the sequential order of concatenated orthogonal coiled-coil (CC) dimer-forming peptides, where a single-chain protein is programmed to fold into a polyhedral cage....

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Detalles Bibliográficos
Autores principales: Lapenta, Fabio, Aupič, Jana, Vezzoli, Marco, Strmšek, Žiga, Da Vela, Stefano, Svergun, Dmitri I., Carazo, José María, Melero, Roberto, Jerala, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878516/
https://www.ncbi.nlm.nih.gov/pubmed/33574245
http://dx.doi.org/10.1038/s41467-021-21184-6