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Stabilization of the Hinge Region of Human E-selectin Enhances Binding Affinity to Ligands Under Force

INTRODUCTION: E-selectin is a member of the selectin family of cell adhesion molecules expressed on the plasma membrane of inflamed endothelium and facilitates initial leukocyte tethering and subsequent cell rolling during the early stages of the inflammatory response via binding to glycoproteins ex...

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Detalles Bibliográficos
Autores principales: Cao, Thong M., King, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878631/
https://www.ncbi.nlm.nih.gov/pubmed/33633813
http://dx.doi.org/10.1007/s12195-021-00666-z