Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation

The bile salt export pump (BSEP) is responsible for the export of bile acid from hepatocytes. Impaired transcellular transport of bile acids in hepatocytes with mutations in BSEP causes cholestasis. Compensatory mechanisms to regulate the intracellular bile acid concentration in human hepatocytes wi...

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Detalles Bibliográficos
Autores principales: Hayashi, Hisamitsu, Osaka, Shuhei, Sakabe, Kokoro, Fukami, Aiko, Kishimoto, Eriko, Aihara, Eitaro, Sabu, Yusuke, Mizutani, Ayumu, Kusuhara, Hiroyuki, Naritaka, Nakayuki, Zhang, Wujuan, Huppert, Stacey S., Sakabe, Masahide, Nakamura, Takahisa, Hu, Yueh-Chiang, Mayhew, Christopher, Setchell, Kenneth, Takebe, Takanori, Asai, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878720/
https://www.ncbi.nlm.nih.gov/pubmed/33450190
http://dx.doi.org/10.1016/j.stemcr.2020.12.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878720/
https://www.ncbi.nlm.nih.gov/pubmed/33450190
http://dx.doi.org/10.1016/j.stemcr.2020.12.008

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