Using antisense oligonucleotides for the physiological modulation of the alternative splicing of NF1 exon 23a during PC12 neuronal differentiation

Neurofibromatosis Type 1 (NF1) is a genetic condition affecting approximately 1:3500 persons worldwide. The NF1 gene codes for neurofibromin protein, a GTPase activating protein (GAP) and a negative regulator of RAS. The NF1 gene undergoes alternative splicing of exon 23a (E23a) that codes for 21 am...

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Detalles Bibliográficos
Autores principales: Biayna, Josep, Mazuelas, Helena, Gel, Bernat, Terribas, Ernest, Dumbovic, Gabrijela, Rosas, Inma, Fernández-Rodriguez, Juana, Blanco, Ignacio, Castellanos, Elisabeth, Carrió, Meritxell, Lazaro, Conxi, Serra, Eduard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878752/
https://www.ncbi.nlm.nih.gov/pubmed/33574490
http://dx.doi.org/10.1038/s41598-021-83152-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878752/
https://www.ncbi.nlm.nih.gov/pubmed/33574490
http://dx.doi.org/10.1038/s41598-021-83152-w

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