Cargando…

Convergence of biomarkers and risk factor trait loci of coronary artery disease at 3p21.31 and HLA region

Here we seek to identify molecular biomarkers that mediate the effect of risk factors on coronary artery disease (CAD). We perform a SNP-based multiomics data analysis to find biomarkers (probes) causally associated with the risk of CAD within known genomic loci for its risk factors. We identify 78...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nikpay, Majid, McPherson, Ruth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878768/ https://www.ncbi.nlm.nih.gov/pubmed/33574266 http://dx.doi.org/10.1038/s41525-021-00174-z

Ejemplares similares

Structural Diversity and African Origin of the 17q21.31 Inversion Polymorphism
por: Steinberg, Karyn Meltz, et al.
Publicado: (2012)

The influence of 17q21.31 and APOE genetic ancestry on neurodegenerative disease risk
por: Harerimana, Nadia V., et al.
Publicado: (2022)

Increased genetic risk for obesity in premature coronary artery disease
por: Cole, Christopher B, et al.
Publicado: (2016)

Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31
por: Permuth-Wey, Jennifer, et al.
Publicado: (2013)

Menkes disease complicated by concurrent Koolen‐de Vries syndrome (17q21.31 deletion)
por: Woodfin, Taylor, et al.
Publicado: (2019)

Identification and Characterization of Nine Novel X-Chromosomal Short Tandem Repeats on Xp21.1, Xq21.31, and Xq23 Regions
por: Yang, Qinrui, et al.
Publicado: (2021)

Common inversion polymorphism at 17q21.31 affects expression of multiple genes in tissue-specific manner
por: de Jong, Simone, et al.
Publicado: (2012)

KANSL1 gene disruption associated with the full clinical spectrum of 17q21.31 microdeletion syndrome
por: Moreno-Igoa, María, et al.
Publicado: (2015)

Mouse models of 17q21.31 microdeletion and microduplication syndromes highlight the importance of Kansl1 for cognition
por: Arbogast, Thomas, et al.
Publicado: (2017)

Common polymorphic inversions at 17q21.31 and 8p23.1 associate with cancer prognosis
por: Ruiz-Arenas, Carlos, et al.
Publicado: (2019)

An Epigenetic Signature in Peripheral Blood Associated with the Haplotype on 17q21.31, a Risk Factor for Neurodegenerative Tauopathy
por: Li, Yun, et al.
Publicado: (2014)

Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to 3p21.31 in Chinese Population
por: Ke, Juntao, et al.
Publicado: (2016)

Genetic Flux Between H1 and H2 Haplotypes of the 17q21.31 Inversion in European Population
por: Deng, Libin, et al.
Publicado: (2011)

A Case of Psoriatic Disease and Hidradenitis Suppurativa in a Child with Chromosome 17q21.31 Microduplication Syndrome
por: Tolino, Ersilia, et al.
Publicado: (2023)

A Case of 17q21.31 Microduplication and 7q31.33 Microdeletion, Associated with Developmental Delay, Microcephaly, and Mild Dysmorphic Features
por: Mc Cormack, Adrian, et al.
Publicado: (2014)

Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region
por: Bekpen, Cemalettin, et al.
Publicado: (2012)

Association studies between chromosomal regions 1q21.3, 5q21.3, 14q21.2 and 17q21.31 and numbers of children in Poland
por: Clark, Jeremy S. C., et al.
Publicado: (2022)

Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for Asthma in Mexican Children
por: Hancock, Dana B., et al.
Publicado: (2009)

PReS-FINAL-2131: Hunting for biomarkers in juvenile dermatomyositis
por: Bellutti Enders, F, et al.
Publicado: (2013)

Correction: Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for Asthma in Mexican Children
por: Hancock, Dana B., et al.
Publicado: (2009)

De Novo 13q13.3-21.31 deletion involving RB1 gene in a patient with hemangioendothelioma of the liver
por: Rapini, Novella, et al.
Publicado: (2014)

The 3p21.31 genetic locus promotes progression to type 1 diabetes through the CCR2/CCL2 pathway
por: Tran, Paul MH., et al.
Publicado: (2021)

Neolithic expansion and the 17q21.31 inversion in Iberia: an evolutionary approach to H2 haplotype distribution in the Near East and Europe
por: Espinosa, Ibone, et al.
Publicado: (2022)

Loss of heterozygosity for chromosomal regions 15q14-21.1, 17q21.31, and 13q12.3-13.1 and its relevance for prostate cancer
por: Nowacka-Zawisza, Maria, et al.
Publicado: (2015)

Functional Analysis of the TRIB1 Associated Locus Linked to Plasma Triglycerides and Coronary Artery Disease
por: Douvris, Adrianna, et al.
Publicado: (2014)

Epigenome-Wide Study Identified Methylation Sites Associated with the Risk of Obesity
por: Nikpay, Majid, et al.
Publicado: (2021)

Hutterite‐type cataract maps to chromosome 6p21.32‐p21.31, cosegregates with a homozygous mutation in LEMD2, and is associated with sudden cardiac death
por: Boone, Philip M., et al.
Publicado: (2015)

Inherited Xq13.2-q21.31 duplication in a boy with recurrent seizures and pubertal gynecomastia: Clinical, chromosomal and aCGH characterization
por: Linhares, Natália D., et al.
Publicado: (2016)

3p22.1p21.31 microdeletion identifies CCK as Asperger syndrome candidate gene and shows the way for therapeutic strategies in chromosome imbalances
por: Iourov, Ivan Y., et al.
Publicado: (2015)

17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes
por: Bowles, Kathryn R., et al.
Publicado: (2022)

Genomic Regions 10q22.2, 17q21.31, and 2p23.1 Can Contribute to a Lower Lung Function in African Descent Populations
por: Fonseca, Héllen, et al.
Publicado: (2020)

Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21
por: Ostrom, Quinn T., et al.
Publicado: (2018)

Genome and epigenome editing identify CCR9 and SLC6A20 as target genes at the 3p21.31 locus associated with severe COVID-19
por: Yao, Yao, et al.
Publicado: (2021)

Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus
por: Kasela, Silva, et al.
Publicado: (2021)

Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus
por: Kasela, Silva, et al.
Publicado: (2021)

Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci
por: Ning, Lvwen, et al.
Publicado: (2020)

Controleur autonome de fonctions: "AFC" SPS 2131
por: Guillaume, C
Publicado: (1976)

Multiomics Data Analysis Identified CpG Sites That Mediate the Impact of Smoking on Cardiometabolic Traits
por: Nikpay, Majid
Publicado: (2023)

A Swedish Familial Genome-Wide Haplotype Analysis Identified Five Novel Breast Cancer Susceptibility Loci on 9p24.3, 11q22.3, 15q11.2, 16q24.1 and Xq21.31
por: Barnekow, Elin, et al.
Publicado: (2023)

CARMAL Is a Long Non-coding RNA Locus That Regulates MFGE8 Expression
por: Soubeyrand, Sébastien, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4is2h7mefb6obrdgshrrcfn4sv