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Cell-to-Cell Adhesion and Neurogenesis in Human Cortical Development: A Study Comparing 2D Monolayers with 3D Organoid Cultures

Organoids (ORGs) are increasingly used as models of cerebral cortical development. Here, we compared transcriptome and cellular phenotypes between telencephalic ORGs and monolayers (MONs) generated in parallel from three biologically distinct induced pluripotent stem cell (iPSC) lines. Multiple read...

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Detalles Bibliográficos
Autores principales: Scuderi, Soraya, Altobelli, Giovanna G., Cimini, Vincenzo, Coppola, Gianfilippo, Vaccarino, Flora M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878838/
https://www.ncbi.nlm.nih.gov/pubmed/33513360
http://dx.doi.org/10.1016/j.stemcr.2020.12.019