Targeting the DNA replication stress phenotype of KRAS mutant cancer cells

Mutant KRAS is a common tumor driver and frequently confers resistance to anti-cancer treatments such as radiation. DNA replication stress in these tumors may constitute a therapeutic liability but is poorly understood. Here, using single-molecule DNA fiber analysis, we first characterized baseline...

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Detalles Bibliográficos
Autores principales: Al Zubaidi, Tara, Gehrisch, O. H. Fiete, Genois, Marie-Michelle, Liu, Qi, Lu, Shan, Kung, Jong, Xie, Yunhe, Schuemann, Jan, Lu, Hsiao-Ming, Hata, Aaron N., Zou, Lee, Borgmann, Kerstin, Willers, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878884/
https://www.ncbi.nlm.nih.gov/pubmed/33574444
http://dx.doi.org/10.1038/s41598-021-83142-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878884/
https://www.ncbi.nlm.nih.gov/pubmed/33574444
http://dx.doi.org/10.1038/s41598-021-83142-y

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