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Rituximab and obinutuzumab differentially hijack the B cell receptor and NOTCH1 signaling pathways
The anti-CD20 monoclonal antibodies rituximab and obinutuzumab differ in their mechanisms of action, with obinutuzumab evoking greater direct B cell death. To characterize the signaling processes responsible for improved B cell killing by obinutuzumab, we undertook a phosphoproteomics approach and d...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878992/ https://www.ncbi.nlm.nih.gov/pubmed/33615197 http://dx.doi.org/10.1016/j.isci.2021.102089 |