Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke

To investigate the therapeutic mechanism of action of transplanted stem cells and develop exosome-based nanotherapeutics for ischemic stroke, we assessed the effect of exosomes (Exos) produced by human umbilical cord mesenchymal stem cells (hUMSCs) on microglia-mediated neuroinflammation after ische...

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Detalles Bibliográficos
Autores principales: Zhang, Zhongfei, Zou, Xiaoxiong, Zhang, Run, Xie, Yu, Feng, Zhiming, Li, Feng, Han, Jianbang, Sun, Haitao, Ouyang, Qian, Hua, Shiting, Lv, Bingke, Hua, Tian, Liu, Zhizheng, Cai, Yingqian, Zou, Yuxi, Tang, Yanping, Jiang, Xiaodan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880318/
https://www.ncbi.nlm.nih.gov/pubmed/33479185
http://dx.doi.org/10.18632/aging.202466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880318/
https://www.ncbi.nlm.nih.gov/pubmed/33479185
http://dx.doi.org/10.18632/aging.202466

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