Cargando…

Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke

To investigate the therapeutic mechanism of action of transplanted stem cells and develop exosome-based nanotherapeutics for ischemic stroke, we assessed the effect of exosomes (Exos) produced by human umbilical cord mesenchymal stem cells (hUMSCs) on microglia-mediated neuroinflammation after ische...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Zhongfei, Zou, Xiaoxiong, Zhang, Run, Xie, Yu, Feng, Zhiming, Li, Feng, Han, Jianbang, Sun, Haitao, Ouyang, Qian, Hua, Shiting, Lv, Bingke, Hua, Tian, Liu, Zhizheng, Cai, Yingqian, Zou, Yuxi, Tang, Yanping, Jiang, Xiaodan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880318/ https://www.ncbi.nlm.nih.gov/pubmed/33479185 http://dx.doi.org/10.18632/aging.202466

Ejemplares similares

Mesenchymal stem cells protect against TBI-induced pyroptosis in vivo and in vitro through TSG-6
por: Feng, Zhiming, et al.
Publicado: (2022)

MiR-146a Ameliorates Hemoglobin-Induced Microglial Inflammatory Response via TLR4/IRAK1/TRAF6 Associated Pathways
por: Liu, Guang-Jie, et al.
Publicado: (2020)

Hif-1α Overexpression Improves Transplanted Bone Mesenchymal Stem Cells Survival in Rat MCAO Stroke Model
por: Lv, Bingke, et al.
Publicado: (2017)

Activated Microglia Induce Bone Marrow Mesenchymal Stem Cells to Produce Glial Cell-Derived Neurotrophic Factor and Protect Neurons Against Oxygen-Glucose Deprivation Injury
por: Lv, Bingke, et al.
Publicado: (2016)

miR-146a Ameliorates Liver Ischemia/Reperfusion Injury by Suppressing IRAK1 and TRAF6
por: Jiang, Weiwei, et al.
Publicado: (2014)

MicroRNA-146a Contributes to SCI Recovery via Regulating TRAF6 and IRAK1 Expression
por: Wei, Jinsong, et al.
Publicado: (2016)

Correction: miR-146a Ameliorates Liver Ischemia/Reperfusion Injury by Suppressing IRAK1 and TRAF6
por: Jiang, Weiwei, et al.
Publicado: (2023)

miR-146a Enhances the Oncogenicity of Oral Carcinoma by Concomitant Targeting of the IRAK1, TRAF6 and NUMB Genes
por: Hung, Pei-Shi, et al.
Publicado: (2013)

Mice with miR-146a deficiency develop severe gouty arthritis via dysregulation of TRAF 6, IRAK 1 and NALP3 inflammasome
por: Zhang, Quan-Bo, et al.
Publicado: (2018)

miR-146a Attenuates Sepsis-Induced Myocardial Dysfunction by Suppressing IRAK1 and TRAF6 via Targeting ErbB4 Expression
por: An, Rui, et al.
Publicado: (2018)

Bone Marrow-Derived Mesenchymal Stem Cells Maintain the Resting Phenotype of Microglia and Inhibit Microglial Activation
por: Yan, Ke, et al.
Publicado: (2013)

MicroRNA-146a Represses Mycobacteria-Induced Inflammatory Response and Facilitates Bacterial Replication via Targeting IRAK-1 and TRAF-6
por: Li, Shuo, et al.
Publicado: (2013)

The MicroRNA-106a/20b Strongly Enhances the Antitumour Immune Responses of Dendritic Cells Pulsed with Glioma Stem Cells by Targeting STAT3
por: Zhou, Hui, et al.
Publicado: (2022)

MicroRNA-146a negatively regulates inflammation via the IRAK1/TRAF6/NF-κB signaling pathway in dry eye
por: Han, Ruifang, et al.
Publicado: (2023)

Chronic constriction injury-induced microRNA-146a-5p alleviates neuropathic pain through suppression of IRAK1/TRAF6 signaling pathway
por: Wang, Zhiyao, et al.
Publicado: (2018)

Effects of acupuncture on the miR-146a-mediated IRAK1/TRAF6/NF-κB signaling pathway in rats with sarcopenia induced by D-galactose
por: Jin, Jing, et al.
Publicado: (2023)

Effects of norepinephrine on microglial neuroinflammation and neuropathic pain
por: Zou, He‐Lin, et al.
Publicado: (2021)

miR-146a-5p promotes replication of infectious bronchitis virus by targeting IRAK2 and TNFRSF18
por: Liu, Hui, et al.
Publicado: (2018)

BAP31 regulates IRAK1-dependent neuroinflammation in microglia
por: Liu, Xia, et al.
Publicado: (2019)

Overexpression of miR-146b-5p Ameliorates Neonatal Hypoxic Ischemic Encephalopathy by Inhibiting IRAK1/TRAF6/TAK1/NF-αB Signaling
por: Yang, Guang, et al.
Publicado: (2020)

Mesenchymal stem cells inhibit lipopolysaccharide-induced inflammatory responses of BV2 microglial cells through TSG-6
por: Liu, Yi, et al.
Publicado: (2014)

LncRNA MALAT1 promotes high glucose-induced inflammatory response of microglial cells via provoking MyD88/IRAK1/TRAF6 signaling
por: Wang, Li-Qing, et al.
Publicado: (2018)

MicroRNA-146a-5p alleviates lipopolysaccharide-induced NLRP3 inflammasome injury and pro-inflammatory cytokine production via the regulation of TRAF6 and IRAK1 in human umbilical vein endothelial cells (HUVECs)
por: Hou, Jingyuan, et al.
Publicado: (2021)

MicroRNA-146b-5p Suppresses Pro-Inflammatory Mediator Synthesis via Targeting TRAF6, IRAK1, and RELA in Lipopolysaccharide-Stimulated Human Dental Pulp Cells
por: Han, Peifeng, et al.
Publicado: (2023)

Neuroinflammation, autoinflammation, splenomegaly and anemia caused by bi-allelic mutations in IRAK4
por: Cooray, Samantha, et al.
Publicado: (2023)

miR‑146a‑5p negatively regulates the IL‑1β‑stimulated inflammatory response via downregulation of the IRAK1/TRAF6 signaling pathway in human intestinal epithelial cells
por: Li, Yanli, et al.
Publicado: (2022)

MiR-146b-5p/TRAF6 axis is essential for Ginkgo biloba L. extract GBE to attenuate LPS-induced neuroinflammation
por: Liu, Min, et al.
Publicado: (2022)

Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels
por: Geng, Degui, et al.
Publicado: (2020)

miR-146b-5p Enhances the Sensitivity of NSCLC to EGFR Tyrosine Kinase Inhibitors by Regulating the IRAK1/NF-κB Pathway
por: Liu, Yi-Nan, et al.
Publicado: (2020)

Regulation of MiR-146a and TRAF6 in the Diagnose of Lupus Nephritis
por: Zhu, Yunfeng, et al.
Publicado: (2017)

MicroRNA-146a switches microglial phenotypes to resist the pathological processes and cognitive degradation of Alzheimer's disease
por: Liang, Chunmei, et al.
Publicado: (2021)

IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis
por: Wang, Yuanyuan, et al.
Publicado: (2023)

Phosphorylation of Microglial IRF5 and IRF4 by IRAK4 Regulates Inflammatory Responses to Ischemia
por: Ngwa, Conelius, et al.
Publicado: (2021)

YTHDC1-Modified m6A Methylation of Hsa_circ_0102678 Promotes Keratinocyte Inflammation Induced by Cutibacterium acnes Biofilm through Regulating miR-146a/TRAF6 and IRAK1 Axis
por: Zhou, Meng, et al.
Publicado: (2023)

MicroRNA-146a Ameliorates Inflammation via TRAF6/NF-κB Pathway in Intervertebral Disc Cells
por: Lv, Feng, et al.
Publicado: (2017)

Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS
por: Duan, Hongxia, et al.
Publicado: (2013)

A Modeling-Derived Hypothesis on Chronicity in Respiratory Diseases: Desensitized Pathogen Recognition Secondary to Hyperactive IRAK/TRAF6 Signaling
por: Zhang, Tingting, et al.
Publicado: (2009)

Tracheal overexpression of IL-1β, IRAK-1 and TRAF-6 mRNA in obese-asthmatic male Wistar rats
por: Aslani, Mohammad Reza, et al.
Publicado: (2016)

Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation
por: Zhou, Fang, et al.
Publicado: (2008)

Ammoxetine attenuates diabetic neuropathic pain through inhibiting microglial activation and neuroinflammation in the spinal cord
por: Zhang, Ting-Ting, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_1qc8p26bg11ffvpumg50u18e6i