Anti-epileptic drug topiramate upregulates TGFβ1 and SOX9 expression in primary embryonic palatal mesenchyme cells: Implications for teratogenicity

Topiramate is an anti-epileptic drug that is commonly prescribed not just to prevent seizures but also migraine headaches, with over 8 million prescriptions dispensed annually. Topiramate use during pregnancy has been linked to significantly increased risk of babies born with orofacial clefts (OFCs)...

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Detalles Bibliográficos
Autores principales: Rafi, Syed K., Goering, Jeremy P., Olm-Shipman, Adam J., Hipp, Lauren A., Ernst, Nicholas J., Wilson, Nathan R., Hall, Everett G., Gunewardena, Sumedha, Saadi, Irfan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880431/
https://www.ncbi.nlm.nih.gov/pubmed/33577554
http://dx.doi.org/10.1371/journal.pone.0246989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880431/
https://www.ncbi.nlm.nih.gov/pubmed/33577554
http://dx.doi.org/10.1371/journal.pone.0246989

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