Tsetse salivary glycoproteins are modified with paucimannosidic N-glycans, are recognised by C-type lectins and bind to trypanosomes

African sleeping sickness is caused by Trypanosoma brucei, a parasite transmitted by the bite of a tsetse fly. Trypanosome infection induces a severe transcriptional downregulation of tsetse genes encoding for salivary proteins, which reduces its anti-hemostatic and anti-clotting properties. To bett...

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Detalles Bibliográficos
Autores principales: Kozak, Radoslaw P., Mondragon-Shem, Karina, Williams, Christopher, Rose, Clair, Perally, Samirah, Caljon, Guy, Van Den Abbeele, Jan, Wongtrakul-Kish, Katherine, Gardner, Richard A., Spencer, Daniel, Lehane, Michael J., Acosta-Serrano, Álvaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880456/
https://www.ncbi.nlm.nih.gov/pubmed/33529215
http://dx.doi.org/10.1371/journal.pntd.0009071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880456/
https://www.ncbi.nlm.nih.gov/pubmed/33529215
http://dx.doi.org/10.1371/journal.pntd.0009071

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