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Prostaglandin E(2) promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells

The gut microbiota fundamentally regulates intestinal homeostasis and disease partially through mechanisms that involve modulation of regulatory T cells (T(regs)), yet how the microbiota-T(reg) cross-talk is physiologically controlled is incompletely defined. Here, we report that prostaglandin E(2)...

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Detalles Bibliográficos
Autores principales: Crittenden, Siobhan, Goepp, Marie, Pollock, Jolinda, Robb, Calum T., Smyth, Danielle J., Zhou, You, Andrews, Robert, Tyrrell, Victoria, Gkikas, Konstantinos, Adima, Alexander, O’Connor, Richard A., Davies, Luke, Li, Xue-Feng, Yao, Hatti X., Ho, Gwo-Tzer, Zheng, Xiaozhong, Mair, Amil, Vermeren, Sonja, Qian, Bin-Zhi, Mole, Damian J., Gerasimidis, Konstantinos, Schwarze, Jürgen K. J., Breyer, Richard M., Arends, Mark J., O’Donnell, Valerie B., Iredale, John P., Anderton, Stephen M., Narumiya, Shuh, Maizels, Rick M., Rossi, Adriano G., Howie, Sarah E., Yao, Chengcan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880593/
https://www.ncbi.nlm.nih.gov/pubmed/33579710
http://dx.doi.org/10.1126/sciadv.abd7954