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Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome
Mitochondrial dysfunction is an established hallmark of aging and neurodegenerative disorders such as Down syndrome (DS) and Alzheimer’s disease (AD). Using a high-resolution density gradient separation of extracellular vesicles (EVs) isolated from murine and human DS and diploid control brains, we...
Autores principales: | D’Acunzo, Pasquale, Pérez-González, Rocío, Kim, Yohan, Hargash, Tal, Miller, Chelsea, Alldred, Melissa J., Erdjument-Bromage, Hediye, Penikalapati, Sai C., Pawlik, Monika, Saito, Mitsuo, Saito, Mariko, Ginsberg, Stephen D., Neubert, Thomas A., Goulbourne, Chris N., Levy, Efrat |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880603/ https://www.ncbi.nlm.nih.gov/pubmed/33579698 http://dx.doi.org/10.1126/sciadv.abe5085 |
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