Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells

Dengue virus (DENV) cycles between mosquito and mammalian hosts. To examine how DENV populations adapt to these different host environments, we used serial passage in human and mosquito cell lines and estimated fitness effects for all single-nucleotide variants in these populations using ultra-deep...

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Detalles Bibliográficos
Autores principales: Dolan, Patrick T, Taguwa, Shuhei, Rangel, Mauricio Aguilar, Acevedo, Ashley, Hagai, Tzachi, Andino, Raul, Frydman, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880689/
https://www.ncbi.nlm.nih.gov/pubmed/33491648
http://dx.doi.org/10.7554/eLife.61921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880689/
https://www.ncbi.nlm.nih.gov/pubmed/33491648
http://dx.doi.org/10.7554/eLife.61921

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