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Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation

Building a genotype-phenotype-fitness map of adaptation is a central goal in evolutionary biology. It is difficult even when adaptive mutations are known because it is hard to enumerate which phenotypes make these mutations adaptive. We address this problem by first quantifying how the fitness of hu...

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Detalles Bibliográficos
Autores principales: Kinsler, Grant, Geiler-Samerotte, Kerry, Petrov, Dmitri A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880691/
https://www.ncbi.nlm.nih.gov/pubmed/33263280
http://dx.doi.org/10.7554/eLife.61271