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Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation

Building a genotype-phenotype-fitness map of adaptation is a central goal in evolutionary biology. It is difficult even when adaptive mutations are known because it is hard to enumerate which phenotypes make these mutations adaptive. We address this problem by first quantifying how the fitness of hu...

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Autores principales: Kinsler, Grant, Geiler-Samerotte, Kerry, Petrov, Dmitri A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880691/
https://www.ncbi.nlm.nih.gov/pubmed/33263280
http://dx.doi.org/10.7554/eLife.61271
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author Kinsler, Grant
Geiler-Samerotte, Kerry
Petrov, Dmitri A
author_facet Kinsler, Grant
Geiler-Samerotte, Kerry
Petrov, Dmitri A
author_sort Kinsler, Grant
collection PubMed
description Building a genotype-phenotype-fitness map of adaptation is a central goal in evolutionary biology. It is difficult even when adaptive mutations are known because it is hard to enumerate which phenotypes make these mutations adaptive. We address this problem by first quantifying how the fitness of hundreds of adaptive yeast mutants responds to subtle environmental shifts. We then model the number of phenotypes these mutations collectively influence by decomposing these patterns of fitness variation. We find that a small number of inferred phenotypes can predict fitness of the adaptive mutations near their original glucose-limited evolution condition. Importantly, inferred phenotypes that matter little to fitness at or near the evolution condition can matter strongly in distant environments. This suggests that adaptive mutations are locally modular — affecting a small number of phenotypes that matter to fitness in the environment where they evolved — yet globally pleiotropic — affecting additional phenotypes that may reduce or improve fitness in new environments.
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spelling pubmed-78806912021-02-16 Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation Kinsler, Grant Geiler-Samerotte, Kerry Petrov, Dmitri A eLife Evolutionary Biology Building a genotype-phenotype-fitness map of adaptation is a central goal in evolutionary biology. It is difficult even when adaptive mutations are known because it is hard to enumerate which phenotypes make these mutations adaptive. We address this problem by first quantifying how the fitness of hundreds of adaptive yeast mutants responds to subtle environmental shifts. We then model the number of phenotypes these mutations collectively influence by decomposing these patterns of fitness variation. We find that a small number of inferred phenotypes can predict fitness of the adaptive mutations near their original glucose-limited evolution condition. Importantly, inferred phenotypes that matter little to fitness at or near the evolution condition can matter strongly in distant environments. This suggests that adaptive mutations are locally modular — affecting a small number of phenotypes that matter to fitness in the environment where they evolved — yet globally pleiotropic — affecting additional phenotypes that may reduce or improve fitness in new environments. eLife Sciences Publications, Ltd 2020-12-02 /pmc/articles/PMC7880691/ /pubmed/33263280 http://dx.doi.org/10.7554/eLife.61271 Text en © 2020, Kinsler et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Evolutionary Biology
Kinsler, Grant
Geiler-Samerotte, Kerry
Petrov, Dmitri A
Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation
title Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation
title_full Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation
title_fullStr Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation
title_full_unstemmed Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation
title_short Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation
title_sort fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation
topic Evolutionary Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880691/
https://www.ncbi.nlm.nih.gov/pubmed/33263280
http://dx.doi.org/10.7554/eLife.61271
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AT petrovdmitria fitnessvariationacrosssubtleenvironmentalperturbationsrevealslocalmodularityandglobalpleiotropyofadaptation