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ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells
The response to Poly (ADP-ribose) polymerase inhibitors (PARPi) is dictated by homologous recombination (HR) DNA repair and the abundance of lesions that trap PARP enzymes. It remains unclear, however, if the established role of PARP in promoting chromatin accessibility impacts viability in these se...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880902/ https://www.ncbi.nlm.nih.gov/pubmed/33462394 http://dx.doi.org/10.1038/s41556-020-00624-3 |