The acute transcriptional responses to dietary methionine restriction are triggered by inhibition of ternary complex formation and linked to Erk1/2, mTOR, and ATF4

The initial sensing of dietary methionine restriction (MR) occurs in the liver where it activates an integrated stress response (ISR) that quickly reduces methionine utilization. The ISR program is regulated in part by ATF4, but ATF4’s prototypical upstream regulator, eIF2α, is not acutely activated...

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Detalles Bibliográficos
Autores principales: Stone, Kirsten P., Ghosh, Sujoy, Kovalik, Jean Paul, Orgeron, Manda, Wanders, Desiree, Sims, Landon C., Gettys, Thomas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880992/
https://www.ncbi.nlm.nih.gov/pubmed/33580171
http://dx.doi.org/10.1038/s41598-021-83380-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880992/
https://www.ncbi.nlm.nih.gov/pubmed/33580171
http://dx.doi.org/10.1038/s41598-021-83380-0

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