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Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells
Genotoxic colibactin-producing pks+ Escherichia coli induce DNA double-strand breaks, mutations, and promote tumor development in mouse models of colorectal cancer (CRC). Colibactin’s distinct mutational signature is reflected in human CRC, suggesting a causal link. Here, we investigate its transfor...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881031/ https://www.ncbi.nlm.nih.gov/pubmed/33579932 http://dx.doi.org/10.1038/s41467-021-21162-y |