Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells

Genotoxic colibactin-producing pks+ Escherichia coli induce DNA double-strand breaks, mutations, and promote tumor development in mouse models of colorectal cancer (CRC). Colibactin’s distinct mutational signature is reflected in human CRC, suggesting a causal link. Here, we investigate its transfor...

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Detalles Bibliográficos
Autores principales: Iftekhar, Amina, Berger, Hilmar, Bouznad, Nassim, Heuberger, Julian, Boccellato, Francesco, Dobrindt, Ulrich, Hermeking, Heiko, Sigal, Michael, Meyer, Thomas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881031/
https://www.ncbi.nlm.nih.gov/pubmed/33579932
http://dx.doi.org/10.1038/s41467-021-21162-y

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