Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases

The dysregulation of gene dosage due to duplication or haploinsufficiency is a major cause of autosomal dominant diseases such as Alzheimer’s disease. However, there is currently no rapid and efficient method for manipulating gene dosage in a human model system such as human induced pluripotent stem...

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Detalles Bibliográficos
Autores principales: Ye, Tao, Duan, Yangyang, Tsang, Hayley W. S., Xu, He, Chen, Yuewen, Cao, Han, Chen, Yu, Fu, Amy K. Y., Ip, Nancy Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881037/
https://www.ncbi.nlm.nih.gov/pubmed/33580208
http://dx.doi.org/10.1038/s42003-021-01722-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881037/
https://www.ncbi.nlm.nih.gov/pubmed/33580208
http://dx.doi.org/10.1038/s42003-021-01722-0

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