Targeting galectin-3 with a high-affinity antibody for inhibition of high-grade serous ovarian cancer and other MUC16/CA-125-expressing malignancies

The lectin, galectin-3 (Gal3), has been implicated in a variety of inflammatory and oncogenic processes, including tumor growth, invasion, and metastasis. The interactions of Gal3 and MUC16 represent a potential targetable pathway for the treatment of MUC16-expressing malignancies. We found that the...

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Detalles Bibliográficos
Autores principales: Stasenko, Marina, Smith, Evan, Yeku, Oladapo, Park, Kay J., Laster, Ian, Lee, Kwangkook, Walderich, Sven, Spriggs, Elizabeth, Rueda, Bo, Weigelt, Britta, Zamarin, Dmitriy, Rao, Thapi Dharma, Spriggs, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881041/
https://www.ncbi.nlm.nih.gov/pubmed/33580170
http://dx.doi.org/10.1038/s41598-021-82686-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881041/
https://www.ncbi.nlm.nih.gov/pubmed/33580170
http://dx.doi.org/10.1038/s41598-021-82686-3

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