Using mitochondrial respiration inhibitors to design a novel model of bipolar disorder-like phenotype with construct, face and predictive validity

We mimicked mild mitochondrial-distress robustly reported in bipolar-disorder (BD) by chronic exposure to uniquely low doses of inhibitors of mitochondrial-respiration complexes in vitro and in vivo. Exposure of the neuronal-originating SH-SY5Y cells to very low dose (10 pM) rotenone, a mitochondria...

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Detalles Bibliográficos
Autores principales: Damri, O., Asslih, S., Shemesh, N., Natour, S., Noori, O., Daraushe, A., Einat, H., Kara, N., Las, G., Agam, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881114/
https://www.ncbi.nlm.nih.gov/pubmed/33579900
http://dx.doi.org/10.1038/s41398-021-01215-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881114/
https://www.ncbi.nlm.nih.gov/pubmed/33579900
http://dx.doi.org/10.1038/s41398-021-01215-y

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