Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling

Self-reactive CD8(+) T cells are important mediators of progressive tissue damage in autoimmune diseases, but the molecular program underlying these cells’ functional adaptation is unclear. Here we characterize the transcriptional and epigenetic landscape of self-reactive CD8(+) T cells in a mouse m...

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Detalles Bibliográficos
Autores principales: Page, Nicolas, Lemeille, Sylvain, Vincenti, Ilena, Klimek, Bogna, Mariotte, Alexandre, Wagner, Ingrid, Di Liberto, Giovanni, Kaye, Jonathan, Merkler, Doron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881115/
https://www.ncbi.nlm.nih.gov/pubmed/33579927
http://dx.doi.org/10.1038/s41467-021-21109-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881115/
https://www.ncbi.nlm.nih.gov/pubmed/33579927
http://dx.doi.org/10.1038/s41467-021-21109-3

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