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Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling
Self-reactive CD8(+) T cells are important mediators of progressive tissue damage in autoimmune diseases, but the molecular program underlying these cells’ functional adaptation is unclear. Here we characterize the transcriptional and epigenetic landscape of self-reactive CD8(+) T cells in a mouse m...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881115/ https://www.ncbi.nlm.nih.gov/pubmed/33579927 http://dx.doi.org/10.1038/s41467-021-21109-3 |