EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction

Epigallocatechin gallate (EGCG) from green tea can induce apoptosis in cancerous cells, but the underlying molecular mechanisms remain poorly understood. Using SPR and NMR, here we report a direct, μM interaction between EGCG and the tumor suppressor p53 (K(D) = 1.6 ± 1.4 μM), with the disordered N-...

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Detalles Bibliográficos
Autores principales: Zhao, Jing, Blayney, Alan, Liu, Xiaorong, Gandy, Lauren, Jin, Weihua, Yan, Lufeng, Ha, Jeung-Hoi, Canning, Ashley J., Connelly, Michael, Yang, Chao, Liu, Xinyue, Xiao, Yuanyuan, Cosgrove, Michael S., Solmaz, Sozanne R., Zhang, Yingkai, Ban, David, Chen, Jianhan, Loh, Stewart N., Wang, Chunyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881117/
https://www.ncbi.nlm.nih.gov/pubmed/33579943
http://dx.doi.org/10.1038/s41467-021-21258-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881117/
https://www.ncbi.nlm.nih.gov/pubmed/33579943
http://dx.doi.org/10.1038/s41467-021-21258-5

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