Cholesterol as a modulator of cannabinoid receptor CB(2) signaling

Signaling through integral membrane G protein-coupled receptors (GPCRs) is influenced by lipid composition of cell membranes. By using novel high affinity ligands of human cannabinoid receptor CB(2), we demonstrate that cholesterol increases basal activation levels of the receptor and alters the pha...

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Detalles Bibliográficos
Autores principales: Yeliseev, Alexei, Iyer, Malliga R., Joseph, Thomas T., Coffey, Nathan J., Cinar, Resat, Zoubak, Lioudmila, Kunos, George, Gawrisch, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881127/
https://www.ncbi.nlm.nih.gov/pubmed/33580091
http://dx.doi.org/10.1038/s41598-021-83245-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881127/
https://www.ncbi.nlm.nih.gov/pubmed/33580091
http://dx.doi.org/10.1038/s41598-021-83245-6

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