Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates

Hyperamylinemia induces amylin aggregation and toxicity in the pancreas and contributes to the development of type-2 diabetes (T2D). Cardiac amylin deposition in patients with obesity and T2D was found to accelerate heart dysfunction. Non-human primates (NHPs) have similar genetic, metabolic, and ca...

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Detalles Bibliográficos
Autores principales: Liu, Miao, Li, Nan, Qu, Chun, Gao, Yilin, Wu, Lijie, Hu, Liangbiao George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881154/
https://www.ncbi.nlm.nih.gov/pubmed/33580152
http://dx.doi.org/10.1038/s42003-021-01676-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881154/
https://www.ncbi.nlm.nih.gov/pubmed/33580152
http://dx.doi.org/10.1038/s42003-021-01676-3

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