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Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates

Hyperamylinemia induces amylin aggregation and toxicity in the pancreas and contributes to the development of type-2 diabetes (T2D). Cardiac amylin deposition in patients with obesity and T2D was found to accelerate heart dysfunction. Non-human primates (NHPs) have similar genetic, metabolic, and ca...

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Detalles Bibliográficos
Autores principales:	Liu, Miao, Li, Nan, Qu, Chun, Gao, Yilin, Wu, Lijie, Hu, Liangbiao George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881154/ https://www.ncbi.nlm.nih.gov/pubmed/33580152 http://dx.doi.org/10.1038/s42003-021-01676-3

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